Asymmetric total synthesis of (+)-swainsonine.
نویسندگان
چکیده
A concise asymmetric synthesis of (+)-swainsonine (ent-1) is described starting from 2, which was readily prepared from commercially available l-glutamic acid. The method features installation of the indolizidine ring via an intramolecular cyclisation of α-sulfinyl carbanion as a key step. (+)-Swainsonine was obtained in 11.8% overall yield in 10 steps.
منابع مشابه
Asymmetric synthesis of (-)-swainsonine
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 2 شماره
صفحات -
تاریخ انتشار 2011