Surface modified poly (butyl cyanoacrylate) nanoparticles loaded with indomethacin: preparation and physicochemical characterization

Poly(butylcyanoacrylate) nanoparticles (PBCN) as biodegradable and biocompatible devices have gained interest as a colloidal drug delivery system. Their main technological advantage is the possibility of preparation by anionic polymerization in aqueous medium without addition of any initiator that could have undesirable side effects. Unfortunately, in such conditions arises a problem with the encapsulation of poorly water-soluble drugs. Aiming to overcome this problem the modifying ability of hydroxypropyl-beta-cyclodextrin (HPBCD) in the preparation of PBCN loaded with indomethacin was investigated. Surface modified HPBCD-PBCN were prepared by anionic polymerization of the monomer in the presence of HPBCD. The loading of indomethacin was performed simultaneously with the formation of nanoparticles. The physicochemical characterization of indomethacin loaded HPBCD-PBCN was made by Dynamic Light Scattering, laser Doppler electrophoresis, Infra Red and NMR spectroscopy. All of these verify the presence of the drug into the polymer matrix of nanoparticles.