Kaposi ’ s Sarcoma - Associated Herpesvirus ORF 54 / dUTPase downregulates a ligand for the NK 1 activating receptor
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چکیده
Kaposi’s Sarcoma-Associated Herpesvirus ORF54/dUTPase downregulates a ligand for the NK 1 activating receptor NKp44 2 Alexis Madrid and Don Ganem# 3 4 1 Howard Hughes Medical Institute and GW Hooper Foundation Laboratories 5 University of California, San Francisco CA 94143 6 7 2 Novartis Institutes for Biomedical Research 8 Emeryville, CA 94608 9 10 #Corresponding Author 11 Novartis Institutes for Biomedical Research 12 Emeryville, CA 94608 13 Phone: 510-923-3400 14 Fax: 510-923-3747 15 Email: [email protected] 16 17 18 Condensed title: KSHV downregulation of NKp44L 19 20 21 22 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.00252-12 JVI Accepts, published online ahead of print on 6 June 2012
منابع مشابه
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes long-term latent infection in humans and can cause cancers in endothelial and B cells. A functioning immune system is vital for restricting viral proliferation and preventing KSHV-dependent neoplasms. While natural killer (NK) lymphocytes are known to target virus-infected cells for destruction, their importance in the anti-KSHV immune ...
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