Potentiation of the negative chronotropic and inotropic effects of adenosine by dipyridamole.

CHIBA, S. Potentiation of the Negative Chronotropic and Isotropic Effects of Adenosine by Dipyridamole. Tohoku J. exp. Med ., 1974, 114 (1), 45-48 The isolated right atrium of the dog was perfused with blood led from a support dog. The selective injection of dipyridamole into the sinus node artery at a dose of 1-10 ƒÊg induced a slight negative chronotropic and positive inotropic effect. The administration of 0.3-10 ƒÊg of adenosine caused a negative chronotropic and inotropic effect. The effects induced by adenosine were potentiated by a single injection or a continuous infusion of dipyridamole usually in the duration of adenosine action and frequently in the maximum decreases of the atrial rate and developed tension. -dipyridamole; adenosine; canine atrium; chronotro