IFN-a2a or IFN-b1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study
نویسندگان
چکیده
Infectious Diseases Division, Department of Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Center (KAIMRC), Infection Prevention and Control, King Abdulaziz Medical City, Saudi Arabia; Infection Prevention and Control, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Microbiology Laboratory, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Critical Care, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; Department of Nephrology, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia
منابع مشابه
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets.
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel and highly pathogenic human coronavirus and has quickly spread to other countries in the Middle East, Europe, North Africa and Asia since 2012. Previous studies have shown that MERS-CoV ORF4b antagonizes the early antiviral alpha/beta interferon (IFN-α/β) response, which may significantly contribute to MERS-CoV pathogenesis; how...
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