Transmissible Mink Encephalopathy
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چکیده
Transmissible mink encephalopathy (TME) is a progressive and fatal neurodegenerative disease that affects ranched mink (Neovison (Mustela) vison). Most or all of the adult animals on a ranch may be affected, and once an animal becomes symptomatic, death is inevitable. This disease is still poorly understood. It is very rare, with only a few outbreaks reported in the U.S. and other countries. Outbreaks seem to result from feeding contaminated food containing prions to mink; however, the origin of these prions is unknown. Recent evidence suggests they might be an atypical variant of the bovine spongiform encephalopathy (BSE) agent.
منابع مشابه
Transmissible mink encephalopathy - review of the etiology of a rare prion disease.
We review here the history, neuropathology, clinical picture and molecular data on transmissible mink encephalopathy (TME). This obscure disease is of utmost importance as it is plausible that it represents a transmission of hidden bovine spongiform encephalopathy (BSE) to mink in the USA. Of special interest is the similarity of L-type of BSE and TME. Furthermore, experimental molecular studie...
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Transmissible mink encephalopathy (TME) is a rare disease of ranch-raised mink caused by exposure to an as yet unidentified contaminated food ingredient in the ration. The clinical and pathological similarities between TME and scrapie, together with the indistinguishable physicochemical characteristics of their transmissible agents, suggest that sheep may be the source of infection. However, ex...
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Transmissible mink encephalopathy (TME) is a rare disease of the North American mink, which has never been successfully transmitted to laboratory mice. We generated transgenic mice expressing the mink prion protein (PrP) and inoculated them with TME or the mouse-adapted scrapie strain 79A. TME infected mink PrP-transgenic mice on a murine PrP knockout background. The absolute species barrier be...
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Attempts to demonstrate specific serum antibody or immune complexes in the brains of mink affected with transmissible mink encephalopathy were unsuccessful with serum neutralization and immunofluorescent procedures. These data may be significant, considering the unusual nature of the disease and the biochemical properties of the etiological agent.
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Experimental transmission of the Stetsonville, Wisconsin, U.S.A. source of transmissible mink encephalopathy (TME) to outbred Syrian golden hamsters resulted in two distinct syndromes, termed hyper (HY) and drowsy (DY), that diverge by the third hamster passage. The syndromes differed with respect to clinical signs, incubation period, brain titre, brain lesion profile and pathogenicity in mink....
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