Systemic steroid treatment of paradoxical upgrading reaction in patients with lymph node tuberculosis.
نویسندگان
چکیده
Sir—We appreciate the comments by Sartin et al. [1] on our article [2] encouraging routine HIV testing. For HIV testing to become a routine part of medical care, procedural barriers, including signed informed consent and pretest counseling, need to be reexamined. The policy of obtaining signed informed consent prior to HIV testing was created to protect the privacy of patients at a time when therapy for HIV infection was minimal or nonexistent. Pretesting requirements have not changed in concordance with the development of HAART. Now, with widespread availability of potent antiretrovirals, pretest requirements need to be minimized to increase the number of individuals being offered HIV tests. As noted by Sartin et al. [1], there are already new federal policies in effect to protect patients’ private health information. Pretest counseling also needs to be simplified. As recommended recently by the Centers for Disease Control and Prevention [3], pretest counseling should not be a barrier to testing. Rather than providing information through lengthy counseling, which many healthcare providers might view as overly burdensome, information regarding HIV infection and treatment can be provided in a more succinct form and a more time-efficient manner. Routine HIV testing will not necessarily cause a significant increase in paperwork and testing-associated bureaucracy, if pretest requirements can be modified. HIV testing can be incorporated into other healthcare activities, such as annual examinations. It can also be performed routinely with other routine blood testing unless patients “opt out.” Pretest counseling can be replaced by the provision of information about HIV infection via an appropriate written pamphlet. Further counseling will be necessary only for patients who test positive or those who identify themselves as being at high risk. We advocate, in concert with Sartin et al. [1], a reevaluation of HIV testing policies and procedures in order to eliminate barriers and obstacles to routine HIV testing. The only way to reduce the number of individuals who are unaware of their HIV-infection status is to increase the number of HIV tests being offered. It is time our testing policies catch up with our ability to treat HIV infection.
منابع مشابه
Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis.
In a retrospective analysis, paradoxical deterioration of lymph node tuberculosis in human immunodeficiency virus-uninfected patients was common, occurring in 25 (23%) of 109 patients after treatment had been given for a median of 46 days (interquartile range, 21-139 days) and persisting for a median of 67.5 days (interquartile range, 34-111 days). We found no association between the use of ste...
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INTRODUCTION A paradoxical reaction during antituberculosis treatment is defined as the worsening of pre-existing tuberculosis lesions or the appearance of a new tuberculosis lesion in patients whose clinical symptoms improved with antituberculosis treatment. The median onset time to the development of a paradoxical response has been reported to be about 60 days after the start of treatment. We...
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The introduction of highly active antiretroviral treatment (HAART) during tuberculosis treatment may be followed by a systemic inflammatory and paradoxical reaction with flare of symptoms and lymph node enlargement. This reaction has also been observed in association with the treatment of disseminated Mycobacterium avium complex (MAC) infection, Cytomegalovirus and other opportunistic infection...
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reaction during Tuberculosis treatment in HIV–seronegative patients. Clin Infect Dis. 2006;42:893–5. 4. Cheng V, Ho P, Lee R, Chan KS, Chan KK, Woo PC, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non HIV-infected patients. Eur J Clin Microbiol Infect Dis. 2002;21:803–9. 5. Hawkey CR, Yap T, Pereira J, Moore DA, Davidson RN, Pasvol G, et al. Character...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 41 6 شماره
صفحات -
تاریخ انتشار 2005