Simple and Non-invasive Liver Fibrosis Stage Prediction Method

نویسندگان

  • Tomasz ORCZYK
  • Małgorzata PAŁYS
  • Piotr PORWIK
  • Joanna MUSIALIK
  • Barbara BŁOŃSKA-FAJFROWSKA
چکیده

Evaluation of stage of liver fibrosis in chronic type C hepatitis is very important in patient therapy. Commonly used method for fibrosis stage determination is liver biopsy, but it is an invasive method and also single biopsy does not give the confidence thus it is required to retrieve samples from more than one region of liver [1]. Some non-invasive tests methods are also available, but are expensive due to requirement of using costly, specialized blood sample markers – such commercial methods like: FibroTest by BioPredictive [2] and ELF Test by Siemens [3]. This article describes a simple and non-expensive indirect fibrosis stage prediction method, based on a generic blood test results and also the research method for biomedical data analysis for creating such methods of prediction. The predicting formula or a classifier generated using presented method should be considered as an indirect fibrosis marker.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Determining the progression stages of liver fibrosis in patients with chronic hepatitis B

Introduction: Chronic hepatitis B (CHB) leads to liver fibrosis, its failure, and death in the long term. The stage of fibrosis in CHB patients can also be detected based on the biochemical markers. The aim of this study was to predict the state of liver fibrosis in CHB patients and determine the possibility of patients shifting from a given state to another one. Materials and Methods: This stu...

متن کامل

Simple non-invasive markers as a predictor of fibrosis and viral response in chronic hepatitis C patients.

BACKGROUND/AIMS Chronic hepatitis C has a high prevalence and leads to development of cirrhosis and hepatocellular carcinoma. Liver fibrosis staging is one of the main factors that influence the decision to indicate therapy for chronic hepatitis C carriers. Several simple laboratory tests, scores and indices have been proposed for the non-invasive prediction of hepatic fibrosis in patients with...

متن کامل

Two or More Synchronous Combination of Noninvasive Tests to Increase Accuracy of Liver Fibrosis Assessement in Chronic Hepatitis C; Results From a Cohort of 446 Patients

BACKGROUND The prediction of fibrosis is an essential part of the assessment and management of patients with chronic liver disease. Non-invasive tests (NITs) have a number of advantages over the traditional standard of fibrosis assessment by liver biopsy, including safety, cost-effectiveness, and widespread accessibility. OBJECTIVES The aim of this study was to determine the accuracy of certa...

متن کامل

Assessment of diagnostic value of DWI technique in the evaluation of liver fibrosis

Introduction: The liver fibrosis is caused by extracellular accumulation of cluster, glycos amino glycans and proteoglycans, which this extracellular accumulation may limit the penetration and molecular movement of water in the tissue, so the Diffusion weighted imaging(DWI) technique is due to the sensitivity to the movement and release of water molecules Can show this restrict...

متن کامل

FibroScan® and transient elastography.

The use of non-invasive tests to stage the severity of liver disease (ie. scarring) is now well established in the management of patients with chronic liver disease. This is because assessment of liver scarring provides prognostic information and assists in establishing treatment priorities. One such technique, transient elastography (TE), is a simple, safe and efficient way to estimate liver s...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011