Control of early Salmonella typhimurium growth in innately Salmonella-resistant mice does not require functional T lymphocytes.
نویسندگان
چکیده
منابع مشابه
Immunity to Salmonella typhimurium infection in C3H/HeJ and C3H/HeNCrlBR mice: studies with an aromatic-dependent live S. typhimurium strain as a vaccine.
Immunization with avirulent Salmonella typhimurium strain SL3235, a smooth, aroA- derivative, was shown to induce high levels of resistance to challenge with virulent S. typhimurium in innately hypersusceptible C3H/HeJ mice and inherently resistant C3H/HeNCrlBR mice. Strain SL3235 is one of a class of avirulent aroA- derivatives made from various strains and species of Salmonella that are being...
متن کاملIgh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens.
In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background (Igh-6(-/-)). Igh-6(-/-) mice immunized with a live, attenuated aroA Salmonella enterica serovar Typhimurium vaccine strain showed impaired long-term acquired resistance against the virulent serovar Typhimuri...
متن کاملEffect of Lactobacillus Casei on Hematological and Histopathological Factors in Rats Infected with Salmonella typhimurium
Introduction: Salmonella typhimurium is one of the most important causes of gastrointestinal diseases in humans and animals. Probiotics inhibit pathogens, such as Salmonella Typhimurium by producing antimicrobial compounds. Therefore, this study assessed the protective effect of Lactobacillus casei on hematological factors in rats infected with Salmonella typhimurium with the possibility of sal...
متن کاملInterleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium.
Spleen and peritoneal macrophages obtained from innately resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella typhimurium C5 RP4. Incubating the cells with recombinant gamma interferon (rIFN-gamma) enhanced IL-18 production. A/J mice treated in vivo with anti-IL-18 antibodies showed impaired resistance to infection, with increased bacterial loads in th...
متن کاملVirulent Salmonellae in Innately Susceptible BALB/c Mice
The mechanisms of immunity to salmonellae conferred by immunization with live vaccines were studied by adoptive transfer using the mouse-virulent strain Salnonella typhimurium C5 and innately susceptible BALB/c (by) mice. This organism cannot establish a sublethal infection in naive BALB/c mice. Animals immunized 2 to 3 months earlier with the S. typhimurium SL3261 aroA live vaccine were used a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of immunology
دوره 129 4 شماره
صفحات -
تاریخ انتشار 1982