Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.
نویسندگان
چکیده
Thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics. All isolates were inhibited at concentrations less than or equal to 25 mug/ml, with the exception of 12% of isolates of Enterobacter spp. and 3% of isolates of Serratia marcescens. Its activity decreased with an increase in inoculum concentration of from 10(5) to 10(7) cells per ml.
منابع مشابه
mycin, N-acetylthienamycin and N-acetyldehydrothienamycin from S. cattleya7) and also a group of antibiotics, the epithienamycins A - D from S. flavogriseus.8,9) The olivanic acid derivatives
Streptomyces olivaceus ATCC 31365 produces a family of novel 1S-lactam antibiotics collectively referred to as the olivanic acids. Seven such compounds, MM 4550, MM 13902, MM 17880, MM 22380, MM 22381, MM 22382 and MM 22383 have been identified which have the same carbapenem nucleus but with different side chains attached to the nucleus. The compounds with an (8S) hydroxyethyl substituent and c...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 15 4 شماره
صفحات -
تاریخ انتشار 1979