Bioprospecting of marine Streptomycetes sp. for its antagonistic activity on MDR Pseudomonas aeruginosa and Acinetobacter baumannii isolates
نویسندگان
چکیده
Infectious diseases are the major cause of morbidity and mortality caused by Pseudomonas aeruginosa (P. aeruginosa) and Acinetobacter baumannii (A. baumannii) and have successfully evolved numerous strategies for resisting the action of many antibacterial drugs. They harbor several drug resistant mechanisms such as target alteration, efflux pump, low intrinsic susceptibility and cross-resistance to chemically unrelated classes of antibacterial molecules challenging human health[1]. Extended spectrum betalactamase (ESBL) producing organisms are in the family Enterobacteriaceae commonly in Escherichia coli (E. coli) and Klebsiella pneumonia (K. pneumonia), but infections, PEER REVIEW ABSTRACT
منابع مشابه
Comparison of E-test and disc diffusion methods for the in vitro evaluation of the antimicrobial activity of colistin in multi-drug resistant Gram-negative Bacilli.
OBJECTIVE To study susceptibility of clinical isolates of multi-drug resistant (MDR) Gram-negative bacilli to colistin by minimum inhibitory concentration (MIC) determination using Etest, and compare this with their susceptibility measured by the disc diffusion (DD) method. METHODS A total of 224 of MDR organisms (147 Acinetobacter baumannii [A. baumannii], 49 Acinetobacter species, 24 Stenot...
متن کاملEmergence of Carbapenem-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Clinical Isolates Collected from Some Libyan Hospitals.
The aim of the present study was to investigate the molecular mechanism of carbapenem resistance in Pseudomonas aeruginosa and Acinetobacter baumannii clinical isolates recovered from Libyan hospitals between April 2013 and April 2014. In total, 49 strains (24 P. aeruginosa and 25 A. baumannii) were isolated, including 21 P. aeruginosa and 22 A. baumannii isolates (87.75%) resistant to imipenem...
متن کاملEvaluation of Anti biofilm and Antibiotic Potentiation Activities of Silver Nanoparticles Against some Nosocomial Pathogens
Nowadays silver nanoparticles (AgNPs) are used as antimicrobial due to its well known physical, chemical, and biological properties. A large collection of bacterial cells adhering to a surface is called bacterial biofilm. Exposure to silver nano particles (AgNPs) may prevent colonization of new bacteria onto the biofilm. In the present work, we have investigated whether the biofilm format...
متن کاملBactericidal activity of herbal volatile oil extracts against multidrug-resistant Acinetobacter baumannii
AIM The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal (Alpinia galanga Linn.), ginger (Zingiber officinale), plai (Zingiber cassumunar Roxb.), lime (Citrus aurantifolia), kaffir lime (Citrus hystrix DC.), sweet basil (Ocimum basilicum Linn.), tree basil (Ocimum gratissimum), lemongrass (Cymbopogon citratus D...
متن کاملEvaluation of growth inhibition activity of myxobacterial extracts against multi-drug resistant Acinetobacter baumannii
The worldwide dissemination of multi drug resistant Acinetobacter baumannii strains has caused serious concern and high rate of mortality in recent decades that originate from limited effective antibiotics in the treatment of A. baumannii infections. Myxobacteria are Gram-negative bacteria that are important for their complex lifestyle and production of novel structurally secondary metabolites ...
متن کامل