Cyclosporin neurotoxicity after chemotherapy.

نویسندگان

  • D A Tweddle
  • K P Windebank
  • Q C Hewson
  • S M Yule
چکیده

Contributors: DEW designed the audit, collected and analysed the data, and participated in writing the paper with EHB. EHB provided DEW with the list of subjects to be investigated, discussed core ideas, and participated in writing the paper; she maintains the database of mothers who are hepatitis B positive and advises on appropriate immunisations. EHB will act as guarantor for the paper. Competing interests: None declared.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Central nervous system toxicity of cyclosporin A treatment in rheumatoid arthritis.

A 35-yr-old woman with rheumatoid arthritis, receiving cyclosporin A, presented with diplopia, ptosis, loss of horizontal and vertical eye movements, dysarthria, nasal regurgitation. After differential diagnosis, cyclosporin A neurotoxicity was suspected and the treatment stopped. All side-effects were reversed with the discontinuation of the drug. Central nervous system neurotoxicity with low-...

متن کامل

Convulsions associated with cyclosporin A in renal transplant recipients.

Cyclosporin A has proved to be a valuable drug both in the prevention of graft rejection after solid organ transplantation' and in the prevention of graft versus host disease after bone marrow transplantation.2 Caine et al treated the first cadaver renal allograft recipients with cyclosporin A in 1978,3 and toxicity due to the drug was noted soon afterwards. The adverse effects in transplant re...

متن کامل

Dysarthria and cerebellar ataxia: late occurrence of severe neurotoxicity in a liver transplant recipient.

Neurological complications of cyclosporin (CyA) therapy are frequent, usually occurring within the 1st month after transplantation. Though leukoencephalopathy is one of them, it is rarely documented. Here we report the case of an anti-HCV-positive patient with cirrhosis who underwent liver transplantation and developed cyclosporin-induced leukoencephalopathy. The presenting symptoms were dysart...

متن کامل

Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.

BACKGROUND AND PURPOSE The etiology of the neurotoxicity associated with cyclosporin-A (CsA) and FK-506 treatment is not fully understood. At our institution, we noticed a distinct, abrupt change in the imaging characteristics of CsA and FK-506 neurotoxicity, which consisted of a shift in lesion morphology from a white matter abnormality to a mixed cortical and white matter pattern. The purpose...

متن کامل

Change of hyperexcitability of hippocampus by cyclosporin A and its modulatory action by fentanyl.

Cyclosporin A is used to treat patients with immune-mediated diseases, chronic diseases requiring organ transplantation, or malignancies. These conditions often require higher cyclosporin A doses, which may be toxic to the central nervous system. Fentanyl is also used in clinical conditions that have a risk of hypoxic neurosusceptibility, which suggests that the drug may be a neuroprotective ag...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • BMJ

دوره 318 7191  شماره 

صفحات  -

تاریخ انتشار 1999