One-hour blood xylose
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چکیده
A retrospective analysis o f oral D-xylose tolerance tests in 435 pediatric patients was performed A significant difference was found between l26 control subject s and 47 untreated children with celiac disease one hour after load. The one-hour value was found to be more reliable than was fecal fa t analysis in screening children for celiac disease. Sex, age, weight, and body surface did not influence the results o f the one-hour value in the control subjects. Forty-eight children with cys'tic fibrosis had one-hour xylose levels' within the normal range, but the means at 90, 120, and 180 minutes' after load exceeded significantly (P < 0.01) those o f the controls. In a nonceHac group o f 63 children with abnormally low xylose levels, almost all were found to have clinical conditions compatible with upper small bowel mucosal impairment. This study shows that a singl e estimation o f xylqse in blood one hour after load is" a reliable index o f small bowel mucosalJhnctionl It is a good screening test for celiac disease and small bowel disorders producing malabsorption in children.
منابع مشابه
One-hour blood-xylose in cystic fibrosis.
One-hour blood-xylose concentrations after an oral xylose load were measured in children with cystic fibrosis (CF) and healthy controls. The mean of the 1-hour blood-xylose values was significantly increased in the group with CF. The finding confirms an earlier observation by Rolles et al. (1973). Its significance is not at present understood but it suggests that small intestinal function shoul...
متن کاملLimitations of xylose tolerance test as a screening procedure in childhood coeliac disease.
The usefulness of the xylose tolerance test as a screening procedure for coeliac disease has been reassessed in 54 children with suspected coeliac disease. 5- and 24-hour urinary excretion rates of xylose were of no value in discriminating between patients with and without coeliac disease; similarly, the 3-hour blood xylose concentration was nondiscriminatory. Three (15-8%) patients with subtot...
متن کاملNeonatal gut function, measured by the one hour blood D (+) xylose test: influence of gestational age and size.
D(+) Xylose absorption, assessed by one hour blood xylose levels, has been measured after intraduodenal infusion of the sugar in 35 infants of differing gestational age and size. The test was performed between the 2nd and 6th days of life. Full-term appropriately grown infants had higher blood xylose levels (1.41+/-0.07 mmol/l) at one hour than pre-term appropriately grown infants (1.17+/-0.07 ...
متن کاملValue of 1-hour blood-xylose test in diagnosis of childhood coeliac disease.
In a series of 46 children with untreated coeliac disease and in 102 controls with normal mucosa the 1-hour blood-xylose test was, in view of its simplicity, of much value in the diagnosis of childhood coeliac disease. Only one blood-xylose result was falsely normal in the 46 coeliac patients. It is concluded that a normal blood-xylose value does not exclude coeliac disease and should not prev...
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In young infants the clinical and investigative features of coeliac disease (CD) may be mimicked by other conditions such as cow's milk intolerance or secondary disaccharidase deficiency. It is therefore especially important to confirm a diagnosis of CD by later gluten challenge in such infants. Sixteen children in whom the diagnosis of CD had been made before the age of 12 months had an oral g...
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