Clonal Evolution Predicts Poor Prognosis in Chronic Lymphocytic Leukaemia and Is As Significant A Marker of Poor Prognosis as High Risk Cytogenetic Markers 17p- and 11q-: A Population Based Cohort study of FISH Testing in British Columbia, Canada
نویسندگان
چکیده
Adam C. Smith1, Krystal Bergin2, Alina S. Gerrie2, Steven J.T. Huang3, Helene Bruyere3, Chinmay B. Dalal2, Khaled M. Ramadan4, Monica Hrynchak5, Aly Karsan6, Cynthia L. Toze2, Tanya L. Gillan3. 1 Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil 2 British Columbia Cancer Agency, Vancouver, Canada 3 Vancouver General Hospital, Vancouver, Canada 4 Division of Hematology, St. Paul’s Hospital, Vancouver, Canada 5 Royal Columbian Hospital, New Westminster, Canada 6 BC Genome Sciences Centre, Vancouver Canada
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BACKGROUND High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution. DESIGN AND ...
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