SIRT3 regulation of keratinocyte differentiation
نویسندگان
چکیده
Background: SIRT3 plays a major role in protecting against mitochondrial oxidative stress. Results: Oxidative stress increases during keratinocyte differentiation, and SIRT3 can decrease differentiation by attenuating oxidative stress. Conclusion: SIRT3-induced down regulation of mitochondrial oxidative stress attenuates keratinocyte differentiation. Significance: Understanding the regulation of keratinocyte differentiation is crucial for developing new therapies against dysregulated skin differentiation and aging.
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