Calreticulin mutation does not modify the IPSET score for predicting the risk of thrombosis among 1150 patients with essential thrombocythemia.
نویسندگان
چکیده
Acknowledgments:Theauthors thankSafia ElMessaoudi andAlainR. Thierry (Institut de Recherche en Cancérologie de Montpellier, Montpellier, France) for technical advice in ASQ-PCR. We also appreciate Masanori Ohta for immunohistochemical analysis and the medical staff in the Department of Hematology/Oncology, Research Hospital, Institute of Medical Science, The University of Tokyo, for collecting samples from patients.
منابع مشابه
[Essential thrombocythemia: baseline characteristics and risk factors for survival and thrombosis in a series of 214 patients].
BACKGROUND AND OBJECTIVE Two prognostic models to predict overall survival and thrombosis-free survival have been proposed: International Prognostic Score for Essential Thrombocythemia (IPSET) and IPSET-Thrombosis, respectively, based on age, leukocytes count, history of previous thrombosis, the presence of cardiovascular risk factors and the JAK2 mutational status. The aim of the present study...
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Diagnosis of essential thrombocythemia (ET) has been updated in the last World Health Organization (WHO) classification. We developed a prognostic model to predict survival at diagnosis, named IPSET (International Prognostic Score for ET), studying patients with WHO-defined ET. Age 60 years or older, leukocyte count ≥ 11 × 10(9)/L, and prior thrombosis significantly affected survival, by multiv...
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Accurate prediction of thrombosis in essential thrombocythemia (ET) provides the platform for prospective studies exploring preventive measures. Current risk stratification for thrombosis in ET is 2-tiered and considers low- and high-risk categories based on the respective absence or presence of either age > 60 years or history of thrombosis. In an international study of 891 patients with World...
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ورودعنوان ژورنال:
- Blood
دوره 124 16 شماره
صفحات -
تاریخ انتشار 2014