Lactic acid formation in muscle extracts: The relationship between phosphoric ester accumulation and phosphoric ester breakdown and lactic acid formation from glycogen.
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چکیده
منابع مشابه
THE FORMATION OF GLUCOSE-l-PHOSPHORIC ACID IN EXTRACTS OF MAMMALIAN TISSUES AND OF YEAST
The initial stages of fermentation of glycogen to lactic acid in muscle have been investigated only recently. It was shown (1, 2) that the glycolytic reactions are initiated by the formation of glucose-l-phosphoric acid from glycogen and inorganic phosphate, an enzymatic process in which adenylic acid acts as coenzyme. The glucose-l-phosphoric acid (l-ester) is converted to glucose-6phosphoric ...
متن کاملLxxv. Studies in Glycolysis Ii. the First Stages of Glycolysis in Muscle Extract;
IN a previous communication [Kendal & Stickland, 1937, 1] it was shown that if rabbit muscle is minced and thoroughly washed with water, and then extracted several times with dilute Na2HPO4, the later extracts (usually the 4th) contain much of the glycolytic enzyme system but are freer from coenzymes than extracts prepared by earlier methods. This was shown by the fact that on addition of boile...
متن کاملTHE ENZYMATIC CONVERSION OF GLTJCOSE-l-PHOS- PHORIC ESTER TO 6-ESTER IN TISSUE EXTRACTS*
The formation of glucose-l-phosphoric acid (l-ester) and its conversion to glucose-6-phosphoric acid have been shown to be initial steps in the degradation of glycogen to lactic acid (1). The enzyme which brings about the conversion of the l-ester has been found in extracts of rabbit muscle, brain, heart, liver, in dog and frog muscle extracts, and in extracts of yeast (2); it is presumably pre...
متن کاملXcv. Role of Glutathione in Anaerobic Tissue Glycolysis
THE relative amounts of lactic acid produced anaerobically by animal tissues from glycogen and from glucose depend on the tissue. Skeletal muscles, while able to form a large quantity of lactic acid from glycogen, produce only a relatively small amount of lactic acid from glucose. On the other hand involuntary muscles, brain tissue, heart muscle and lungs produce far more lactic acid from gluco...
متن کاملThe mechanism by which glyceraldehyde inhibits glycolysis.
In 1929 Mendel (1) discovered that nL-glyceraldehyde in concentrations of 1O-3 M almost completely inhibited the anaerobic formation of lactic acid from glucose by rat sarcoma. Glyceraldehyde, even in much higher concentrations, did not appreciably affect the respiration of normal liver, kidney, and brain, or of malignant cells. Somewhat later Mendel, Bauch, and Strelitz (2) found that the addi...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 22 3 شماره
صفحات -
تاریخ انتشار 2005