Deletions of the Cyclin - Dependent Kinase Inhibitor Genes p 161 NK 4 * and ~ 1 5 ' ~ ~ ~ ~ in Non - Hodgkin ' s Lymphomas
نویسندگان
چکیده
The tumor suppressor genes p16'NK4A and ~ 1 5 ' ~ " ~ map to the 9p21 chromosomal locus and are either homozygously deleted or mutated in a wide range of human cancer cell lines and tumors. Although chromosome 9 abnormalities have been described in non-Hodgkin's lymphomas [NHLs), to date, the mutational status of these genes has not been determined for these malignancies. A total of five cell lines and 75 NHLs were examined for homozygous deletions or point mutations in the coding regions of both the p15 and p16 genes using Southern blot and/or polymerase chain reaction-single-strand conformation polymorphism analyses.
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