PARP1 – Another factor of stemness?

Received: July 25, 2016; Accepted: August 08, 2016; Published: August 08, 2016 The pluripotency of embryonic stem cells, which are capable of unlimited self-renewal and differentiation into every type of cell in the body, is provided by the extensive expression of genes encoding stemness factors, among which the transcription factors such as Sox2, Pou5f1, Nanog are most frequently enumerated [1]. These proteins interact with specific sequences in the regulatory elements of cell typespecific and/or cell cycle regulating genes thereby rescuing cell from the differentiation process. Recent findings have shed the light on DNAinteracting genome guardian – PARP1, which might be considered as another player in the complex stemness game [2].