Polyamine depletion influences drug-induced chromosomal damage.
نویسندگان
چکیده
Polyamines have been implicated in the intracellular stabilization of DNA. Depletion of intracellular polyamines influences the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II. By means of the sister chromatid exchange assay, it was found that intracellular polyamine depletion can also alter the induction of chromosomal damage by these cytotoxic agents.
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ورودعنوان ژورنال:
- Science
دوره 217 4564 شماره
صفحات -
تاریخ انتشار 1982