Erythrocyte Aldehyde Dehydrogenase = a Potential Marker for Alcohol Dependence
نویسندگان
چکیده
The present study explored the utility of erythrocyte aldehyde dehydrogenase (ALDH) as a peripheral marker in alcoholism. The ALDH levels in aocoholics, their first degree nonalcholic relative and controls were compared. ALDH was found to be significantly lower in alcoholics (3.38±1.70 mU p< 0.001) and their first degree relatives (4.04±1.55 mU p< 0.05) compared to controls (5.06±1 55mU). Low ALDH levels among alcoholics persisted despite abstinence. The levels did not correlate with indices of hepatic dysfunction or with severity of alcoholism. These findings indicate that low erythrocyte ALDH may be considered as a biochemical trait marker associated with alcoholics, and the alcohol abuse would further decrease enzyme activitiy. To evaluate this proposition, logitudinal studies involving high risk progeny of alcohol dependents is being planned.
منابع مشابه
Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins.
AIM Aldehyde dehydrogenase 1 (ALDH1) has been advocated as a marker of alcohol intake. The absence or low levels of ALDH1 may be associated with alcohol-induced flushing or other reactions to alcohol in Europeans and therefore, with reduced alcohol use. This study tested whether variation in erythrocyte ALDH1 activity was associated with alcohol use, alcohol dependence or reactions to alcohol i...
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