The In Vivo Transport of Anionic Contrast Agent into Human Femoral Knee cartilage
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چکیده
INTRODUCTION Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a quantitative MRI method utilizing anionic contrast agent Gd-DTPA. The suggested mechanism is that the fixed charge density (FCD) of cartilage, induced by glycosaminoglycans (GAG), dictates the contrast agent distribution in cartilage via electrostatic repulsion [1]. However, this assumption has not been thoroughly examined and confirmed. Furthermore, very little is known about temporal and spatial transport patterns. This knowledge would be important for interpreting dGEMRIC results with respect to cartilage molecular structure. The aim of the present study was to investigate the transport of Gd-DTPA into human knee cartilage in vivo.
منابع مشابه
Analysis of diffusion kinetics of anionic and cationic iodinated contrast agents using in-vivo CT imaging of rabbit knee cartilage
INTRODUCTION: Contrast Enhanced CT imaging of articular cartilage (CECT) is predicated on the use of positively or negatively charged contrast agents that function as mobile ionic probes that partition themselves in direct or indirect proportion to the glycosaminoglycan (GAG) content of the cartilage matrix according to Donnan equilibrium. Ex-vivo studies have shown that CECT imaging of cartila...
متن کاملThe In Vivo Transport of Anionic Contrast Agent into Human Femoral Knee cartilage
INTRODUCTION Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) is a quantitative MRI method utilizing anionic contrast agent Gd-DTPA. The suggested mechanism is that the fixed charge density (FCD) of cartilage, induced by glycosaminoglycans (GAG), dictates the contrast agent distribution in cartilage via electrostatic repulsion [1]. However, this assumption has not been thoroughly examined...
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OBJECTIVE We investigated the feasibility of delayed computed tomography (CT) arthrography for evaluation of human knee cartilage in vivo. Especially, the diffusion of contrast agent out of the joint space and the optimal time points for imaging were determined. DESIGN Two patients were imaged using delayed CT arthrography and delayed gadolinium-enhanced magnetic resonance imaging of cartilag...
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