1 Nootkatone , a characteristic constituent of grapefruit , stimulates energy metabolism and 1 prevents diet - induced obesity by activating AMPK 2 3
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چکیده
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and 1 prevents diet-induced obesity by activating AMPK 2 3 Takatoshi Murase, Koichi Misawa, Satoshi Haramizu, Yoshihiko Minegishi, and Tadashi Hase 4 5 Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 6 321-3497, Japan 7 Running head: Nootkatone activates AMPK 8 9 Address correspondence to: Takatoshi Murase, PhD, Biological Science Laboratories, Kao 10 Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. 11 Phone: +81-285-68-7844 12 Fax: +81-285-68-7495 13 E-mail: [email protected] 14 15 Abbreviations: ACC: acetyl-CoA carboxylase, AMPK: adenosine monophosphate-activated protein 16 kinase, CaMKK: calmodulin-dependent protein kinase kinase, PPAR: peroxisome 17 proliferator-activated receptors, RNS: reactive nitrogen species, ROS: reactive oxygen species, RQ: 18 respiratory quotient. 19 20 Articles in PresS. Am J Physiol Endocrinol Metab (May 25, 2010). doi:10.1152/ajpendo.00774.2009
منابع مشابه
Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPK.
AMP-activated protein kinase (AMPK) is a serine/threonine kinase that is implicated in the control of energy metabolism and is considered to be a molecular target for the suppression of obesity and the treatment of metabolic syndrome. Here, we identified and characterized nootkatone, a constituent of grapefruit, as a naturally occurring AMPK activator. Nootkatone induced an increase in AMPKalph...
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