Summary report on first, second and third generation smallpox vaccines
ثبت نشده
چکیده
Content Background .................................................................................................................................................... 3 First generation smallpox vaccines ............................................................................................................... 3 Second generation vaccines ........................................................................................................................ 11 Third generation vaccines ........................................................................................................................... 15 Other smallpox vaccines .............................................................................................................................. 26 Ethical considerations ................................................................................................................................. 27 References ................................................................................................................................................... 29
منابع مشابه
A Historical Investigation into Combatting Smallpox in Iran: 1948–1967 (First to Third Development Projects)
Smallpox was a dangerous disease that was considered one of the leading causes of mortality and disability in Iran up to Pahlavi II period. Therefore, combatting this disease was necessary. At the beginning of the second development plan (1955) and by founding Combatting Smallpox Service, the efforts for eradicating smallpox became more organized. This organization could overcome a lot of the d...
متن کاملEvolution, benefits, and shortcomings of vaccine management.
BACKGROUND The reduction of childhood mortality by vaccines has been one of the greatest public health successes of the past century. However, many targets for immunization remain uncontrolled, and new or improved vaccines are emerging to meet these challenges. OBJECTIVE To review the evolution of vaccination and take an objective look at current vaccine development technologies, thereby fram...
متن کاملIdentification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.
Despite worldwide eradication of naturally occurring variola virus, smallpox remains a potential threat to both civilian and military populations. New, safe smallpox vaccines are being developed, and there is an urgent need for methods to evaluate vaccine efficacy after immunization. Here we report the identification of an immunodominant HLA-A*0201-restricted epitope that is recognized by cytot...
متن کاملA Review on Current Status and Future Potential of Transdermal Patches as a Promising Drug Delivery System
Transdermal patches are now widely used in topical and transdermal drug delivery systems (TDDS). Up to now, TDDS has been used in several conditions, such as smoking cessation, analgesic effect, nausea, contraception, and hormone therapy. Basically, there are two types of transdermal patches: the reservoir-type patches and the matrix-type patches. First generation TDDS were designed for deliver...
متن کاملSmallpox vaccines: New formulations and revised strategies for vaccination.
Smallpox has been eradicated but stockpiles of the causative infectious agent, variola virus, have been maintained over decades. Today, the threat of accidental or intentional poxvirus release is accompanied by the fact that the existing licensed smallpox vaccines cause rare but severe adverse reactions yet are the only products with approved efficacy against smallpox. New safer vaccines and ne...
متن کامل