Synthesis and Antimicrobial Study of Pyrimidinone Substituted 4(3H)-Quinazolinone Derivatives

Heterocyclic scaffold has been under discovery due to their considerable therapeutic and medicinal importance. One of such heterocycles 2-pyrimidinone, while not naturally occurring, are receiving increased attention because of their wide-ranging biological activity like, an efficient inhibitor of DNA synthesis in E. coli, inhibitors of the enzyme cytidinedeaminase, and as metaphase inhibitors. Such pyrimidinone derivatives and the pharmaceutical acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, thereby, being useful in treating cardiovascular disease caused by binding angiotensin II to its receptor. Antitumor activity of pyrimidinones derivatives have shown statistically significant synergism with cyclophosphamide (CY) against antitumor / P388 leukemia etc. [1-7]. They have also shown anticancer [8,9], potent TF-FVIIa inhibitors [10] and inhibition of C5-cytosine DNA methyltransferases [11] activities.