On-Line Monitoring of Particle Shape and Size Distribution in Crystallization Processes through Image Analysis

On-line monitoring and control of particle shape and size distribution is important in pharmaceutical and fine chemical manufacturing. In this paper, we describe a methodology for real-time estimation of particle quality variables during crystallization using inline process video-images. Our approach integrates image analysis techniques with multivariate statistical techniques to quantify particle shape and size. This information can then be used for process monitoring and control. In this work, we demonstrate applications to systems with high particle concentration.