Pathogenic Studies of Methicillin Resistant Staphylococcus Aureus Isolates from Biomedical Wastes

Staphylococcus aureus is naturally present in the nasal membranes and skin of warm blooded animals including human beings. It can grow in aerobic and anaerobic conditions, forming grape-like clusters. It causes a range of infections from mild, such as skin infections and food poisoning to life threatening, such as pneumonia, sepsis, oseteomyelitis and infectious endocarditis. Methicillin Resistant Staphylococcus aureus (MRSA) isolated from clinical samples, band aid, cloth and cotton collected from hospitals and clinical laboratories in various parts of Tamilnadu. All MRSA isolates were transferred to nutrient agar containing 5% sodium chloride and 3 gm of oxacillin antibiotic. MRSA isolates were properly diluted with sterile saline and injected to tail vein of mice. After 14th day mice were dissected, liver and kidneys were selected for histopathological studies. MRSA injected mice group showed different pathogenic characters like lesions, white coloured patches, cellulitis and necrosis when compared with control group.