Neurobiology of Disease Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of -Synucleinopathy
نویسندگان
چکیده
Rainer von Coelln,1,2* Bobby Thomas,1,2* Shaida A. Andrabi,1,2 Kah Leong Lim,1,2 Joseph M. Savitt,1,2 Roya Saffary,1,2 Wanda Stirling,5 Kristy Bruno,2 Ellen J. Hess,2 Michael K. Lee,5 Valina L. Dawson,1,2,3,4 and Ted M. Dawson1,2,3 1Institute for Cell Engineering, Departments of 2Neurology, 3Neuroscience, 4Physiology, and 5Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
منابع مشابه
Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recessive parkinsonism, protects against alpha-synuclein-mediated toxicity in various models.We analyzed the effects of Parkin deficiency in a mous...
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