Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma

نویسندگان

  • Despo Ierodiakonou
  • Michael A. Portelli
  • Dirkje S. Postma
  • Gerard H. Koppelman
  • Jorrit Gerritsen
  • Nick H.T. ten Hacken
  • Wim Timens
  • H. Marike Boezen
  • Judith M. Vonk
  • Ian Sayers
چکیده

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uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium

BACKGROUND The asthma-associated gene urokinase plasminogen activator receptor (uPAR) may be involved in epithelial repair and airway remodelling. These processes are not adequately targeted by existing asthma therapies. A fuller understanding of the pathways involved in remodelling may lead to development of new therapeutic opportunities. uPAR expression in the lung epithelium of normal subjec...

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Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients.

RATIONALE Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen activator receptor (uPAR/PLAUR) have been associated with lung function decline and uPAR blood levels in asthma subjects. Preliminary studies have identified uPAR elevation in asthma; however, a definitive study regarding which clinical features of asthma uPAR may be driving is currently lacking. OBJECTIV...

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Relationship of Circulating Soluble Urokinase Plasminogen Activator Receptor (suPAR) Levels to Disease Control in Asthma and Asthmatic Pregnancy

Asthma has a high burden of morbidity if not controlled and may frequently complicate pregnancy, posing a risk for pregnancy outcomes. Elevated plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is related to a worse prognosis in many conditions such as infectious, autoimmune, or pregnancy-related diseases; however the value of suPAR in asthma an...

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Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia.

Developing gene therapy for cystic fibrosis has been hindered by limited binding and endocytosis of vectors by human airway epithelia. Here we show that the apical membrane of airway epithelia express the urokinase plasminogen activator receptor (uPAR). Urokinase plasminogen activator (uPA), or a 7-residue peptide derived from this protein (u7-peptide), bound the receptor and stimulated apical ...

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SERPINE1 -675 4G/5G polymorphism is associated with asthma severity and inhaled corticosteroid response.

Asthma is characterised by chronic airway inflammation and remodelling, which can be (partially) suppressed by inhaled corticosteroids (ICSs). Plasminogen activator inhibitor-1, encoded by the SERPINE1 gene, is the key inhibitor of the plasminogen activator system, which affects tissue repair and remodelling. We studied associations between a functional SERPINE1 -675 4G/5G promoter polymorphism...

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عنوان ژورنال:

دوره 47  شماره 

صفحات  -

تاریخ انتشار 2016