Tetrabutyrate on Inactivation of Rat Liver Microsomal Enzymes Induced by Carbon Tetrachloride 1
نویسنده
چکیده
It has been postulated that hepatotoxicity of carbon tetrachloride is related to its prooxidant effect on lipid peroxidation (1-8). DIANZANI and UGAZIO (8) reported that several antioxidants, i.e., propyl gallate, N, N•L-diphenyl-p-phenyl enediamine, and reduced glutathione, which are administered to rats prior to carbon tetrachloride, inhibit significantly the accumulation of hepatic triglycerides. Preventive effect on hepatic injury is also observed for ƒ¿-tocopherol (9-10). It has also been reported that some microsomal enzymes are inactivated by dosing rats with carbon tetrachloride and that inactivation is prevented by administration of antioxidants prior to hepatotoxin (11-14). Furthermore, it was observed that inactivation of membrane-bound enzymes is associated with production of malon aldehyde (7, 15, 16), which is known to be formed from the decomposition of
منابع مشابه
اثر عصارهی هیدروالکلی برگ گیاه غافث (Agrimonia eupatoria L.) بر سمیت کبدی در موشهای صحرایی نر القا شده با تتراکلرید کربن
Background and Objective: Carbon tetrachloride (CCl4) is a toxic agent leading to hepatotoxicity. The aim of this study was to investigate the effect of Agrimonia eupatoria leaf hydroalcoholic extract (AEE) on carbon tetrachloride induced rat liver. Materials and Methods: In this study, 42 male rats were randomly allocated to 6 groups: the control group receiving normal saline, 2ml/kg, ip and ...
متن کاملReduced glutathione protection against rat liver microsomal injury by carbon tetrachloride. Dependence on O2.
Rat liver microsomal membranes contain a reduced-glutathione-dependent protein(s) that inhibits lipid peroxidation in the ascorbate/iron microsomal lipid peroxidation system. It appears to exert its protective effect by scavenging free radicals. The present work was carried out to assess the effect of this reduced-glutathione-dependent mechanism on carbon tetrachloride-induced microsomal injury...
متن کاملLipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride.
Lipid peroxidation is known to affect the activity of several enzymes including microsomal enzymes such as glucose-6-phosphatase; but its effect on the enzymes of lipid biosynthesis has not been investigated. Glycerol-3-phosphate acyltransferase (GPAT) represents the first committed step and probably the rate limiting step in glycerolipid synthesis and thus may be a good candidate for study. Ra...
متن کاملAntioxidant and Hepatoprotective Effects of Bauhinia racemosa Against Paracetamol and Carbon Tetrachloride Induced Liver Damage in Rats
The methanol extract of Bauhinia racemosa Lam. (Caesalpiniaceae) stem bark was investigated for the antioxidant and hepatoprotective effects in Wistar albino rats. Different groups of animals were administered with paracetamol (500 mg/kg, (p.o.) once in a day for 7 days) and carbon tetrachloride (CCl4) (30 % CCl4, 1 ml/kg b.wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The methanol e...
متن کاملProtective Effect of Ricinus communis Leaves Extract on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats
Ricinus communis Linn. (Euphorbiaceae) is a soft wooded tree widely prevalent throughout tropics regions of the world which have a warm temperature. In the Indian system of medicine, the leaves, roots and seed oil of this plant have been used for the treatment of inflammation and liver disorders for a lo...
متن کامل