Studies on the fetal hemoglobin in the persistent high Hb-F anomaly.
نویسندگان
چکیده
منابع مشابه
The Influence of Fetal Hemoglobin on Clinical and Hematological Variables of Children and Adolescents with Sickle Cell Anemia in Basra, Southern Iraq
Background: There are many parameters that modulate the severity of sickle cell anemia. Fetal hemoglobin (Hb F) is one of these major variables. However, its effect is clinically inconsistent. We conducted a descriptive study to assess the influence of Hb F on clinical events and hematological variables in patients with sickle cell anemia. Methods: 151 patients with sickle cell anemia with a st...
متن کاملOn the chemical abnormality of Hb "Alexandra", a fetal hemoglobin variant.
H UMAN FETAL HEMOGLOBIN consists of two unlike pairs of polypeptide chains, i.e., a2y2. While the detection of an a-chain variant may not present serious difficulties, since the abnormal fetal hemoglobin will be replaced by the adult type, the y-chain variants are transitory and their study is limited by time, shortage of blood and their rarity. Identification of the y-chain anomaly has been po...
متن کاملبررسی ارتباط پلی‌مورفیسم ژن BCL11A با میزان بیان ژن گاما گلوبین و مقدار هموگلوبین F در افراد مبتلا به بیماری بتا تالاسمی اینترمدیا در جمعیت اصفهان
Background: A Thalassemia intermedium is an autosomal recessive disease that from clinical and also genotypic view contains a very heterogeneous group of hemoglobinopathies and severity of disease is placed between thalassemia major and minor. High levels of fetal hemoglobin have a major impact on the severity of this disease, so that increased production of HbF, reduces these veritie...
متن کاملFetal hemoglobin and hemolysis markers in sickle cell anemia☆
It has been known for many years that high levels of fetal hemoglobin (Hb F) have an important clinical benefit in patients with sickle cell anemia (SCA). This knowledge was initially based on the observation that populations of Indian and Arabian SCA patients with high Hb F levels have a milder clinical form of the disease.1 Later on, epidemiological studies demonstrated that patients with Hb ...
متن کاملLevel of Hemoglobin F and Gg Gene Expression in Sickle Cell Disease and Their Association with Haplotype and XmnI Polymorphic Site in South of Iran
Background: Molecular genetic factors regulating hemoglobin F (Hb F) expression are important modifiers of the severity of sickle cell anemia (SS). Methods: The prevalence of XmnI polymorphic site, the Gg:Ag ratio and the Hb F level were determined using PCR-RFLP procedure, HPLC and alkaline denaturation method, respectively, in various haplotypes of 52 patients with SS, 18 patients with sickle...
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ورودعنوان ژورنال:
- Blood
دوره 18 شماره
صفحات -
تاریخ انتشار 1961