Dry extract BNO 1011 inhibits human influenza a replication and neuraminidase activity in oseltamivir-resistant and -sensitive viral strains
نویسندگان
چکیده
Background Virus infection is the main triggering event for the development of acute rhinosinusitis and human influenza A virus ranks among the most frequent viral causes of infection. Influenza neuraminidase, a key enzyme in viral replication, spread, and pathogenesis, is the primary target in prevention and treatment of influenza infection. Sinupret, a herbal medicinal product composed of Gentianae radix, Primulae flos, Sambuci flos, Rumicis herba, and Verbenae herba, is frequently used for the treatment of acute rhinosinusitis.
منابع مشابه
An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro
Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg/mL against influenza virus A/WSN/33. TDSWex had excellent antiviral efficacy ...
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