Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in in vitro gut inflammation.
نویسندگان
چکیده
A system for assessing the anti-inflammatory effects of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells and macrophage RAW264.7 cells. The results indicate that fucoidan and lentinan exhibited different suppressive effects on interleukin-8 (IL-8) mRNA expression in Caco-2 through tumor necrosis factor-alpha (TNF-alpha) production from RAW264.7 stimulated with lipopolysaccharide (LPS).
منابع مشابه
Intestinal Anti-Inflammatory Activity of Lentinan: Influence on IL-8 and TNFR1 Expression in Intestinal Epithelial Cells
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. It is unknown whether β-1,3;1,6-glucan can induce immune suppressive effects. Here, we study intestinal anti-inflammatory activity of Lentinula edodes-derived β-1,3;1,6-glucan, which is known as lentinan. Dextran sulfate sodium (DSS)-induced colitis mice were used to elucidate effects of len...
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 73 10 شماره
صفحات -
تاریخ انتشار 2009