Regulatory Toxicology and Pharmacology
نویسنده
چکیده
Agency for Toxic Substances and Disease Registry (ATSDR) utilizes chemical-specific minimal risk lev els (MRLs) to assist in evaluating the public health risk associated with exposure to hazardous sub stances. The MRLs are derived based on the health effects data compiled from current literature searches and presented in ATSDR's toxicological profiles. Health effects are categorized according to their degree of severity (e.g., serious, less serious, minimal, and not adverse). This evaluation is impor tant, because each respective category can be as signed a different amount of uncertainty, thus af fecting the final value of the calculated MRL. From the total of 272 MRLs derived as of December 1997, 21 were based on developmental effects. ATSDR's ranking of developmental health effects as de scribed in the Guidance for Developing Toxicological Profiles and specific examples of how the catego rized health effects were used in MRL derivations are provided in this paper.
منابع مشابه
Comments on the safety assessment of decamethylcyclopentasiloxane (D5) published in regulatory toxicology and pharmacology, 2017, 83:117-118.
This letter is in response to the summary of the safety assessment of the Scientific Committee on Consumer Safety (SCCS) on decamethylcyclopentasiloxane (D5) in cosmetic products published (SCCS & Rousselle, 2017) and the opinion (SCCS, 2017). We have been asked by the Silicones Environmental, Health and Safety Center of the American Chemistry Council to provide comments given that SCCS (2017) ...
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