Abnormal diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease following corneal transplantations.

نویسندگان

  • Alejandro A Rabinstein
  • Michelle L Whiteman
  • Robert T Shebert
چکیده

BACKGROUND The value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic cases of Creutzfeldt-Jakob disease has been questioned. OBJECTIVE To illustrate the value of magnetic resonance imaging of the brain in the diagnosis of iatrogenic Creutzfeldt-Jakob disease. METHODS Case report. RESULTS A patient with a history of 3 corneal transplantations exhibited the alien hand sign on initial examination. Diffusion-weighted magnetic resonance imaging of the brain revealed prominent cortical diffusion abnormalities. During the following months, the patient developed rapidly progressive dementia. The diagnosis of Creutzfeldt-Jakob disease was proven by brain biopsy. CONCLUSION Brain magnetic resonance imaging, particularly diffusion-weighted magnetic resonance imaging, can be very helpful in the diagnosis of Creutzfeldt-Jakob disease, even in suspected iatrogenic cases.

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Abnormal diffusion-weighted magnetic resonance images in Creutzfeldt-Jakob disease.

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عنوان ژورنال:
  • Archives of neurology

دوره 59 4  شماره 

صفحات  -

تاریخ انتشار 2002