Neonatal diabetes mellitus.

Genetic Susceptibility to Transient and Permanent Neonatal Diabetes Mellitus

Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...

Molecular basis of transient neonatal diabetes mellitus in Japan: frequent KATP-TNDM and identification of a patient with a monoallelic INS mutation

Clinical and Molecular Genetic Analysis of Iranian Patients with Neonatal Diabetes demonstrating Mutations in KCNJ11 gene

Abstract We screened the KCNJ11 gene from 35 individuals clinically diagnosed with type 1 diabetes mellitus under the age of 6 months in 3 years duration. Six different heterozygous missense mutations were found in 7 of the 35 probands, which accounted for 20% of all individuals. A novel mutation W68R (No Locus, GU170814; 2009) was identified in the kir6.2, the pore-forming subunit of the KATP ...

Neonatal diabetes mellitus.

Neonatal diabetes mellitus is a rare form of insulin dependent diabetes mellitus that present within the first month of life, lasting at least two weeks and requiring insulin therapy. Intrauterine growth restriction, failure to thrive, fever, dehydration, hyperglycemia and acidosis with or without ketonuria are the clinical features of the disease. We report four cases of neonatal diabetes mell...

Comparison of pregnancy complications between gestational diabetes mellitus and normal group in Iran: a cohort study

Introduction: To compare the incidence of fetal, maternal and neonatal complications amongst women with gestational diabetes mellitus (GDM) and pregnant women with normal glucose tolerance in Shahrood. Materials and Methods: In order to compare fetal and maternal complications, for all pregnant women who were referred from private clinics and health care settings to Fatemiyeh Hospital for scree...

Congenital Diabetes Mellitus.

Introduction: Neonatal diabetes is a rare and surprising diagnosis, with many complications and difficult management by the medical team. Objectives: Management of the diabetes mellitus new-born in our maternity. Matherial and methods:Analysis of one of the rare cases of diagnosed neonatal diabetes. Conclusions:Given the rarity of such cases, this event can guide the medical care team consistin...