The Japanese Society of Toxicology NII - Electronic

.....The mutagenic potential o ξ thiamazole , an antith ア agent , was investigated bア an in vivo cytogenetic test and was compared with those of mitomycin C and vincristin . These drugs were subcutaneously inlected into slc −ICR male mice e童ther as a single dose or asmult 三ple doses for 5succcssive days, Thiamazole(900r 180 mg /kg)dld not increase the number of micronuclei in bone marrow ceUs . Thls drug also did not induce chromosomal aberra . tions in spermatogonium , spermatocyte , or bone marrow cells . On the other hand , mitomycin C (3.O mg /kg)increased the appearance of chromosomal aberrations and micronucle 量. Vincristin (02 mg /kg)induced bone marrow cells with a so called large micronucleus (d≧ D /4), These results suggest that thiamazole may not have significant effects on the genetic sア of mice .