Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila.
نویسندگان
چکیده
Mutations in the human neurotrypsin gene are associated with autosomal recessive mental retardation. To further understand the pathophysiological consequences of the lack of this serine protease, we studied Tequila (Teq), the Drosophila neurotrypsin ortholog, using associative memory as a behavioral readout. We found that teq inactivation resulted in a long-term memory (LTM)-specific defect. After LTM conditioning of wild-type flies, teq expression transiently increased in the mushroom bodies. Moreover, specific inhibition of teq expression in adult mushroom bodies resulted in a reversible LTM defect. Hence, the Teq pathway is essential for information processing in Drosophila.
منابع مشابه
Response to Comment on “Tequila, a Neurotrypsin Ortholog, Regulates Long- Term Memory Formation in Drosophila”
We previously showed that Tequila (Teq), a neurotrypsin ortholog, regulates long-term memory formation in Drosophila (1). The orthology of Teq and neurotrypsin had been recognized by several online databases, including FlyBase, Homophila (Human disease to Drosophila gene database), Ensembl.Moreover, a previous comparison based on protein sequence and domain-organization comparisons (Online Mend...
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ورودعنوان ژورنال:
- Science
دوره 313 5788 شماره
صفحات -
تاریخ انتشار 2006