Neurocognitive and Mood Effects of Nutrition and Nutraceuticals

Cognitive processes involve multiple mechanisms that interact in complex and possibly idiosyncratic ways. This complexity likely underlies the general lack of meaningful impact of monopharmacological (or “magic bullet”’) approaches to brain dysfunction, including cognitive decline and dementia. For example, the cholinesterase inhibitors used in the treatment of Alzheimer’s disease (AD) have a narrow therapeutic window and are effective only at certain stages of the disorder. This is perhaps unsurprising considering that the onset and progression of AD are influenced by numerous other processes, as well as cholinergic degeneration.