Familial Mediterranean Fever and Human autoinflammatory diseases

Introduction Human Autoinflammatory Diseases (HADs) is a heterogeneous group of rare genetic diseases, which are characterized by unprovoked onsets of inflammation, fever and clinical symptoms analogous with rheumatic diseases with absence of immunological indicators. Familial Mediterranean Diseases (FMF) is one of the popular forms in the group of syndromes which are called HPFS. Clinical characterization is presented in symptoms which are common for all hereditary fevers like: relapsing onsets of inflammation (serous membrane) of muscularjoint syndrome, various skin rash, high rates of inflammatory processes (ESR, leucocytosis, c-reactive protein, SAA), secondary amyloidosis complications, absence of autoantibodies. Absence of specific symptoms of manifestation hampersdifferential diagnosis. The used diagnostic criteria are insufficient for timely diagnosis of Familial Mediterranean Diseases, especially in case of atypical debut of disease. It is actualforthe group of Hereditary Periodic Fever Syndromes and Human Autoinflammatory Diseases, such as Still’s disease, Crohn’s disease, Bekhchet’s disease and Juvenile Idiopathic Arthritis (JIA) that are characterized by the multifactor types of inheritance.