Fungal PR-1-like protein functions in virulence on mammals
نویسندگان
چکیده
Background: Pathogenesis-related (PR-1like) proteins are widely conserved in eukaryotes, but their biological function is unknown. Results: Knockout or site-directed mutagenesis of fpr1 encoding a secreted PR1-like protein in the fungal pathogen Fusarium oxysporum impairs virulence on mice. Conclusion: Secreted PR-1-like proteins are important for fungal infection of mammals. Significance: First genetic evidence for a biological function of the predicted active site of PR-1-like proteins.
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