[Lung injury in neonates. Causes, strategies for prevention and long-term consequences].

HMD, demonstrating that ventilator strategy can contribute to the progression of HMD. The protective ventilatory strategy used by Meredith et al16 also included an attempt to maximally recruit the lung by using a high mean airway pressure. Although this approach improved gas exchange, the animals developed clinical signs of cardiac compromise. The problems with cardiac output impairment were avoided if, after the lung was recruited, the mean airway pressure was gradually decreased. As a guide, Kinsella et al17 used the chest radiograph and oxygenation (PaO2/partial pressure of oxygen in the alveoli [PAO2]) to