S020 Evaluation of Tumor Hypoxia and Metabolism in Hnscc Using [18f]hx4 and [18f]fdg Pet Imaging
نویسندگان
چکیده
Increased tumor hypoxia and metabolic uptake levels are prognostic factors for worse overall survival and increased radioresistance in patients with head and neck cancer. [18F]HX4 is a novel promising PET tracer for visualization and quantification of tumor hypoxia. The aims of this study were to evaluate the [18F]HX4 uptake, its changes and spatiotemporal stability during treatment and the correlation between [18F]HX4 and [18F]FDG PET. We hypothesize that [18F]HX4 will contribute to a better identification of therapy resistant areas for radiotherapy dose-escalation.
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