Crypts predict the hypertrophic response in HCM mutation carriers
نویسندگان
چکیده
Objectives We BLOCKINused BLOCKINserial BLOCKINcardiovascular BLOCKINmagnetic BLOCKINresonance BLOCKINimaging BLOCKIN(CMR) BLOCKINin BLOCKINmutation BLOCKINcarriers to monitor LV mass, LV function, LV morphology and left atrial (LA) volumes to gain insight BLOCKINin BLOCKINthe BLOCKINnatural BLOCKINcourse BLOCKINof BLOCKINdevelopment BLOCKINof BLOCKINHCM.
منابع مشابه
Multiple myocardial crypts on modified long-axis view are a specific finding in pre-hypertrophic HCM mutation carriers.
AIMS Crypts can be found with cardiovascular magnetic resonance imaging (CMR) in hypertrophic cardiomyopathy (HCM) mutation carriers without hypertrophy (carriers) using a modified two-chamber view through the inferoseptum, but also in other patients and healthy individuals with standard long-axis views. Since it is currently unknown if carriers display a specific crypt morphology, we compared ...
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Hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomeric proteins, the commonest being MYBPC3 encoding myosin-binding protein C. It is characterised by left ventricular hypertrophy but there is an important pre-hypertrophic phenotype with features including crypts, abnormal mitral leaflets and trabeculae. We investigated these during mouse cardiac development using high-resolution...
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Background Sarcomeric gene mutations are responsible for hypertrophic cardiomyopathy (HCM). In gene mutation carriers without significant left ventricular (LV) hypertrophy (G +LVH-), subtle abnormalities can exist as mitral valve elongation, crypts, markers of elevated LV systolic function, and abnormal apical trabeculation. Reverse curvature of the interventricular septum into the LV is a char...
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Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease with prevalence of 0.2% in the population. More than 1000 mutations in more than 10 genes encoding for proteins of the cardiac sarcomere have been identified. Cardiac magnetic resonance imaging (CMR) is used to characterize left ventricular morphology with great precision in patients with HCM and it identifies unique...
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