The structure of the calcium complex of A23187, a divalent cation ionophore antibiotic.
نویسندگان
چکیده
The crystal and molecular structures of the calcium complex of A23187 has been determined by X-ray diffraction studies.
منابع مشابه
The induction of the acrosome reaction in guinea-pig sperm by the divalent metal cation ionophore A23187.
The divalent metal cation ionophore A23187 induces an acrosome reaction in guinea-pig sperm which is dependent on external calcium. Examination of this acrosome reaction by electron microscopy shows that it is morphologically normal. The known properties of A23187 and the morphological similarity between the acrosome reaction and the secretory discharges of other secretory cells suggests that t...
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Background The role of calcium in physiological phenomenona such as sperm acrosome reaction and hyper-activation has been well known. Calcium ionophore A23187 is routinely used for induction of acrosome reaction in mammalians sperm. Therefore, we decided to evaluate the effect of calcium ionophore A23187 on the sperm hyper-active motility patterns. MaterialsAndMethods Ten semen samples from ind...
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Background: Parthenogenetic activation of mammalian oocytes using artificial stimuli is commonly used in various reproductive bio-techniques. Calcium ionophore is known to elevate intracellular calcium levels in the cytoplasm of oocytes through the influx of calcium from extracellular spaces. Ethanol promotes a single intracellular Ca2+ increase of greater and longer amplitude than the initial ...
متن کاملA23187: a divalent cation ionophore.
A23187 is a carboxylic acid antibiotic which simultaneously uncouples oxidative phosphorylation and inhibits ATPase of rat liver mitochondria incubated in a magnesium-free medium. The antibiotic acts as a freely mobile carrier to transport calcium and magnesium, but not potassium, from an aqueous medium buffered at pH 7.4 into a bulk organic phase. A23187 causes a progressive release of endogen...
متن کاملP-97: Parthenogenetic Activation of Mouse Oocyte Using Calcium Ionophore in The Presence of Different Concentrations of Extracellular Calcium
Background: Parthenogenetic activation is a possible way to produce homogeneous embryos with the some ploidy. Probably such embryos could be used in other areas of biotechnology. Calcium signals are known as important regulators of oocyte activation. Extracellular calcium is required for initiation of meiotic resumption and development. Calcium ionophore A23187 is known to elevate intracellular...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 29 4 شماره
صفحات -
تاریخ انتشار 1976