Gap junction-modifying antiarrhythmic peptides: therapeutic potential in atrial fibrillation
نویسندگان
چکیده
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245 Mechanism of arrhythmia in AF . . . . . . . . . . . . . . . . . . . . . . .246 Role of conduction slowing in AF . . . . . . . . . . . . . . . . . . . . .246 Gap junction dysfunction is associated with AF . . . . . . . . . .247 Gap junction-modifying AAPs . . . . . . . . . . . . . . . . . . . . . . . .248 Effects of rotigaptide on atrial conduction . . . . . . . . . . . . . .249 Effects of rotigaptide on atrial arrhythmias . . . . . . . . . . . . . .251 Effects of rotigaptide on atrial refractoriness . . . . . . . . . . . . .253 Safety pharmacology studies with rotigaptide . . . . . . . . . . . .254 Mechanism of action of rotigaptide on atrial tissue . . . . . . . .254 Perspectives and future directions . . . . . . . . . . . . . . . . . . . .255 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .256 Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .256 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .256 Drugs of the Future 2007, 32(3): 245-260 Copyright © 2007 PROUS SCIENCE CCC: 0377-8282/2007 DOI: 10.1358/dof.2006.032.03.1072639
منابع مشابه
Myocardial gap junctions: targets for novel approaches in the prevention of life-threatening cardiac arrhythmias.
Direct cell-to-cell communication in the heart is maintained via gap junction channels composed of proteins termed connexins. Connexin channels ensure molecular and electrical signals propagation and hence are crucial in myocardial synchronization and heart function. Disease-induced gap junctions remodeling and/or an impairment or even block of intercellular communication due to acute pathologi...
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