4-(4-Chlorophenyl)-2,6-bis(1H-indol-3-yl)-1,4-dihydropyridine-3,5-dicarbonitrile ethanol monosolvate
نویسندگان
چکیده
In the title compound, C(29)H(18)ClN(5)·C(2)H(6)O, the dihydro-pyridine ring adopts a strongly flattened envelope conformation, with a maximum deviation of 0.139 (2) Å from its best plane for the Csp(3) atom. The dihedral angles between the dihydro-pyridine ring plane and the two indole rings in positions 2 and 6 are 34.28 (5) and 40.50 (6)°, respectively. In turn, the benzene ring and the dihydro-pyridine ring are oriented at a dihedral angle of 74.69 (6)°. An intra-molecular C-H⋯Cl hydrogen bond occurs. In the crystal, mol-ecules are linked by N-H⋯N, N-H⋯O and O-H⋯N hydrogen bonds into layers parallel to (001). There are short C-H⋯Cl contacts between mol-ecules in neighboring layers.
منابع مشابه
Diethyl 4-[5-(biphenyl-4-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate ethanol monosolvate
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Recent studies showed that 1,4-dihydropyridine-3,5-dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity. In this study, we have synthesized new derivatives of 1,4-dihydropyridines bearing carbmethoxy and carbethoxy group at C-3 and C-5 of the 1,4-dihydropyridine ring. In addition, 1H-pyrazole ring is substituted at C-4 position. These analogues were synthesize...
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