Mutating the second glutamate in the amidase active site 1 The mechanism of the amidases: Mutating the second active site glutamate inactivates the enzyme due to substrate mispositioning*
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چکیده
1 The mechanism of the amidases: Mutating the second active site glutamate inactivates the enzyme due to substrate mispositioning* Brandon W. Weber, Serah W. Kimani, Arvind Varsani, Donald A. Cowan Roger Hunter Gerhard A. Venter and B. Trevor Sewell Structural Biology Research Unit, Division of Medical Biochemistry, Department of Clinical Laboratory Sciences, University of Cape Town, Observatory, Western Cape, 7700, South Africa
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