Desquamative interstitial pneumonia.
نویسندگان
چکیده
The clinical and pathologic findings of 13 cases of desquamative interstitial pneumonia (D IP) are presented. The disease is characterized by large num bers of intra-alveolar mononuclear cells. Eight cases showed mild degrees of fibrosis at the time of biopsy. Six cases had arthritis or clinical and serologic features suggesting altered immunological activity. Three patients died of progressive pulmonary insufficiency, and one patient has progressive pulmo nary disability. The poor outcome of these patients correlated with the pres ence of fibrosis in the biopsy suggests that DIP may be the early stage of some cases of diffuse interstitial pulmonary fibrosis. Leibow, Steer and Billingsley in 1965 first described desquamative interstitial pneumonia (D IP), segregating it from the usual chronic interstitial pneumonias or “UIP” because of the relative lack of fibro sis and more favorable response to steroid therapy. 9 Pathologically, the disease was characterized by large numbers of mono nuclear cells in the alveolar space without evidence of necrosis or hyaline membranes. A subsequent report by Gaensler et al totalling 1 2 cases corroborated the initial report. 3 Only one patient in each series died. Thirteen cases of DIP studied at the Thomas Jefferson University Hospital be tween 1959 and 1969 have been reviewed. Unlike the previous reports, the outcome of this series has not been as favorable. This report will review our experience with this disease.
منابع مشابه
Desquamative interstitial pneumonia: relationship to interstitial fibrosis.
Patchefsky, A. S., Israel, H. L., Hoch, W. S., and Gordon, Gloria (1973). Thorax, 28, 680-693. Desquamative interstitial pneumonia: relationship to interstitial fibrosis. The clinical course and radiographic and pathological findings in 14 patients having the histological pattern of desquamative interstitial pneumonia (DIP) have been studied. Four deaths occurred from cardiorespiratory failure ...
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ورودعنوان ژورنال:
- Annals of clinical and laboratory science
دوره 3 6 شماره
صفحات -
تاریخ انتشار 1973