Fertility in mice after prenatal exposure to benzo[a]pyrene and inorganic lead.

ارزیابی میزان مواجهه تنفسی با بنزو آلفا پیرن(Benzo (a) Pyrene) در آسفالتکاران شهر تهران

Background: Asphalt workers are exposed to dangerous agents in his workplace that might result in occupational diseases. Benzo (a) pyrene as a human carcinogen, is emission from hot asphalt and asphalt workers are exposed with it. The aim of this study was, evaluation of respiratory exposure to benzo (a) pyrene among asphalt workers. Method: In this study, 42 samples were collected from breath...

Baicalein, a flavonoid causes prolonged estrus and suppressed fertility output upon prenatal exposure in female mice

Objective(s): Baicalein (BC), a phytoestrogen of the flavonoid family shows beneficiary and adverse effects. Effect of BC on reproduction is still not understood. Reproductive toxic effects on female mice were tested in this study.Materials and Methods: Inseminated Wistar mice were divided into four groups and administered IP with 30, 60, and 90 mg/Kg body weight of BC on gestation daydays 11, ...

Effects of Prenatal Lipopolysaccharide Exposure on Reproductive Activities and Serum Concentrations of Pituitary-Gonadal Hormones in Mice Offspring

Tumor and Stem Cell Biology Glutathione-Deficient Mice have Increased Sensitivity to Transplacental Benzo[a]pyrene-Induced Premature Ovarian Failure and Ovarian Tumorigenesis

Polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (BaP) are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Prenatal exposure to BaP causes premature reproductive senescence in mice, and other PAHs are transplacental ovarian carcinogens. Glutathione (GSH) is critical for detoxification of the reactive metabolites of PAHs. Therefore, we h...

Increased sensitivity to testicular toxicity of transplacental benzo[a]pyrene exposure in male glutamate cysteine ligase modifier subunit knockout (Gclm-/-) mice.

Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BaP), are ubiquitous environmental pollutants formed by the incomplete combustion of organic materials. The tripeptide glutathione (GSH) is a major antioxidant and is important in detoxification of PAH metabolites. Mice null for the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have ...